AZD3839 ID:1550
Synonyms: |
CAS NO : 1227163-56-5 |
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Molecular Formula: C24H18F3N5 |
Molecular Weight: 433.43 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
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Remarks:AZD3839 is a potent and selective BACE1 inhibitor. AZD3839 is clinical candidate for the treatment of Alzheimer disease. AZD3839 inhibits BACE1 activity, Aβ and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons. Selectivity against BACE2 and cathepsin D was 14 and >1000-fold, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species.
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H-NMR,C-NMR,LC-MS,HPLC. |
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