Cas No. |
Product name |
668467-91-2 |
LDN-57444 |
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LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
459168-41-3 |
JNJ7777120 |
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JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin rec... |
960374-59-8 |
ONX0914(PR-957) |
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ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. |
603139-19-1 |
Odanacatib (MK-0822) |
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Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target... |
147591-46-6 |
ID8 |
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ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. |
1374598-80-7 |
TAK875 |
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TAK-875 is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid. |
847925-91-1 |
RO4929097 |
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RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2. |
1146699-66-2 |
Avagacestat |
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Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectiv... |
208255-80-5 |
DAPT (GSI-IX) |
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DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. |
313967-18-9 |
FLI-06 |
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FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |